Evorel Sequi belongs to a group of medicines called hormone replacement therapy (HRT). Each patch delivers two female hormones through the skin: an oestrogen (estradiol) and a progestogen (norethisterone). The hormones are spread evenly across the patch and pass slowly into your body, replacing those that decline during the menopause.

Evorel Sequi comes in a 'memory pack' to help you remember when to change your patches. Each pack contains eight patches: four Evorel 50 patches marked CE50 (containing estradiol only) and four Evorel Conti patches marked CEN1 (containing estradiol and norethisterone).

Evorel Sequi follows a four-week sequential cycle. For the first two weeks you apply the oestradiol-only Evorel 50 patches, then switch to the combined Evorel Conti patches for the second two weeks. Patches are changed twice weekly. The progestogen phase helps protect the lining of the womb and typically produces a regular monthly bleed.

Evorel Sequi is only used in women who still have a womb. It is suitable for women who are around the time of the menopause (perimenopausal) or who have had the menopause (postmenopausal). It may also be used to prevent osteoporosis in postmenopausal women at risk of bone problems, where other medicines have been tried first without success. During your consultation, our UK-registered clinicians will review your medical history to confirm whether this treatment is right for you.

You may put an Evorel Sequi patch on at any time if:

• You have not used HRT before your menopause and no longer have menstrual periods

• Your menstrual cycles are not regular and you are not pregnant

• You are changing from HRT that does not give you a withdrawal bleed

Put an Evorel 50 patch on within 5 days of the start of bleeding if:

• You are not currently using HRT and still having regular periods

Put an Evorel 50 patch on at the end of a treatment cycle or one week after you finish using another HRT product if:

• You are changing from an HRT medicine that gives you a withdrawal bleed 10

If you are using another type of HRT:

• The day you start will depend on the type of HRT you have been using Talk to your doctor if you are not sure which type of HRT you are using.

Using the patches

The patches need to be changed twice a week. You must use the patches in the right order.

Weeks 1 and 2

Use the four Evorel 50 patches one at a time.

Weeks 3 and 4

Use the four Evorel Conti patches one at a time. As soon as you remove your fourth Evorel 50 patch, replace it with the first Evorel Conti patch. Start a new pack of Evorel Sequi as soon as you finish one. Do not leave a break between packs.

Changing your patches

• You must change the patches twice a week to give your body a steady supply of hormones. There is enough hormone in each patch to last for several days

• Change your patch on the same two days every week. This will mean that one patch is on for three days and the next patch for four days

• For example, if you apply your first patch on a Monday, change it on Thursday and again on the following Monday.

Very common (affects more than 1 in 10 people)

• Irritated, itchy, red skin and rash where the patch is applied

Common (affects less than 1 in 10 people)

• Feeling depressed or nervous

• Inappropriate signs of emotion

• Being unable to sleep

• Headache

• Itchy skin or red rash

• Feeling sick (nausea), or having stomach pain wind or other stomach upsets

• Diarrhea

• Pain including pain in the back, muscles, joints

• Breast pain

• Feeling generally unwell

• Weight gain

• Heavy vaginal bleeding, painful periods

• Water retention or build-up of fluid under the skin (oedema)

Evorel Sequi patches are available to buy online with Pharmulous. The process is simple:

• Complete a short, confidential online consultation
• A GMC or GPhC-registered clinician reviews your answers and approves your prescription
• Your medication is dispensed the same day in plain, discreet packaging
• Free standard UK delivery to your door

Interested in other HRT treatment options? Explore our complete HRT range today.