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Mupirocin 2% Ointment is a topical antibiotic used to treat certain bacterial skin infections, including localised non-bullous impetigo. It works by stopping bacteria from producing proteins needed for growth, helping to clear the infection and promote healing.
Mupirocin is generally reserved for situations where it is considered the most appropriate treatment, such as when other topical treatments are unsuitable or based on clinical judgement. This supports responsible antibiotic prescribing and antimicrobial stewardship.
Following your online consultation, one of our independent prescribers will review your symptoms, medical history and clinical photographs to determine whether Mupirocin 2% Ointment is appropriate for you.
What is Mupirocin 2% Ointment used for?
Mupirocin 2% Ointment is used to treat:
- Localised non-bullous impetigo
- Superficial bacterial skin infections caused by susceptible bacteria
- Skin infections where a topical antibiotic is clinically appropriate
Your clinician will determine whether Mupirocin is the most suitable treatment for your condition.
How does Mupirocin work?
Mupirocin is a topical antibiotic that works by blocking bacterial protein synthesis. Without these essential proteins, bacteria are unable to grow or multiply, allowing the body's natural healing process to clear the infection.
It is active against many of the bacteria commonly responsible for impetigo, including Staphylococcus aureus and Streptococcus pyogenes.
Who can use Mupirocin 2% Ointment?
Mupirocin may be suitable for adults and children with:
- Localised non-bullous impetigo
- Small bacterial skin infections
- Infections suitable for topical antibiotic treatment
Treatment should only be started following assessment by an appropriately qualified healthcare professional.
Who should not use Mupirocin 2% Ointment?
Mupirocin may not be suitable if you:
- Are allergic to mupirocin or any of the ingredients
- Have widespread impetigo requiring oral antibiotics
- Have bullous impetigo
- Have cellulitis or rapidly spreading infection
- Have infection involving or close to the eyes
- Have severe pain, fever or feel generally unwell
- Require urgent face-to-face medical assessment
If your infection is unsuitable for online treatment, your clinician will advise you on the most appropriate next steps.
Directions for Use
Always use Mupirocin 2% Ointment exactly as directed by your prescriber.
Typical directions
- Wash your hands before and after applying the ointment.
- Gently clean and dry the affected area.
- Apply a small amount of ointment to the infected skin.
- Use as directed by your prescriber.
- A light dressing may be applied if recommended by your clinician.
- Complete the full prescribed course, even if symptoms improve sooner.
Avoid contact with the eyes, inside the nose (unless specifically prescribed for nasal use), mouth and other mucous membranes.
Most people use Mupirocin without experiencing significant side effects.
Possible side effects include:
- Mild burning or stinging
- Itching
- Redness
- Dry skin
- Skin irritation
- Rash
Stop using the ointment and seek immediate medical advice if you experience:
- Swelling of the face, lips or tongue
- Difficulty breathing
- Severe skin reaction
- Signs of an allergic reaction
Frequently asked questions
What is Mupirocin 2% Ointment used for?
Mupirocin is used to treat localised bacterial skin infections, including non-bullous impetigo, when a topical antibiotic is clinically appropriate.
Is Mupirocin an antibiotic?
Yes. Mupirocin is a topical antibiotic that stops bacteria from growing, helping the infection to clear.
Why isn't Mupirocin always prescribed first?
To help reduce antibiotic resistance, UK clinical guidance recommends using antibiotics only when they are clinically indicated. Depending on your assessment, your clinician may recommend a non-antibiotic treatment, such as hydrogen peroxide cream, or another topical antibiotic if more appropriate.
How quickly does Mupirocin work?
Many people notice improvement within 2 to 3 days, although you should continue using the ointment for the full prescribed course.
Can I use Mupirocin with other creams?
Avoid applying other creams, ointments or cosmetics to the treated area unless your clinician advises otherwise, as they may reduce the effectiveness of the treatment.
Do I need an online consultation?
Yes. Mupirocin 2% Ointment is supplied only after an online medical assessment reviewed by one of our independent prescribers. You will usually be asked to upload clear photographs of the affected area so your clinician can confirm the diagnosis and determine whether Mupirocin is the most appropriate treatment.


