Nytol Original 25mg Tablets are a pharmacy medicine for the short-term relief of temporary sleeping difficulties in adults and young people aged 16 years and over.

Each tablet contains diphenhydramine hydrochloride 25mg, a sedating antihistamine that causes drowsiness and can help people experiencing temporary sleep problems get to sleep.

For adults and children aged 16 years and over, the usual dose is 2 tablets taken with water approximately 20 minutes before going to bed, providing a total dose of 50mg diphenhydramine. Do not take additional tablets if you wake during the night.

Nytol Original is intended for short-term use only. If sleeping difficulties persist or regularly return, speak to a doctor or pharmacist rather than continuing to self-treat.

Avoid drinking alcohol while taking Nytol Original. The medicine can cause drowsiness and may affect your ability to drive or operate machinery.

Always read the patient information leaflet before use.

Frequently asked questions
  • What is Nytol Original used for?

    Nytol Original is used for the short-term relief of temporary sleeping difficulties.

  • What is the active ingredient?

    Each Nytol Original tablet contains diphenhydramine hydrochloride 25mg.

  • How does Nytol Original work?

    Diphenhydramine is a sedating antihistamine. Its sedative effect causes drowsiness, which can help with temporary difficulty getting to sleep.

  • How many Nytol Original tablets should I take?

    For adults and young people aged 16 years and over, the usual dose is 2 tablets approximately 20 minutes before bedtime.

    Always follow the directions on the pack and patient information leaflet.

  • Why do I take two Nytol Original tablets?

    Each Nytol Original tablet contains 25mg of diphenhydramine. Two tablets provide a total bedtime dose of 50mg.

  • What is the difference between Nytol Original and Nytol One-A-Night?

    The main difference is the amount of diphenhydramine in each tablet:

    • Nytol Original: 25mg per tablet, with two tablets taken at bedtime.
    • Nytol One-A-Night: 50mg per tablet, with one tablet taken at bedtime.

    Both therefore provide 50mg diphenhydramine at the recommended bedtime dose.

  • What age is Nytol Original suitable for?

    Nytol Original is suitable for adults and young people aged 16 years and over. It should not be given to children under 16.

  • How long can I use Nytol Original?

    It is intended for short-term use. Diphenhydramine sleep aids should not be used continuously for longer than 2 weeks without consulting a doctor.

  • Can I drink alcohol while taking Nytol?

    No. Alcohol can increase the sedating effects of diphenhydramine and should be avoided.

  • Can I drive after taking Nytol Original?

    Nytol can cause drowsiness, dizziness, reduced attention and impaired coordination. Do not drive or operate machinery if affected.

  • Can I take Nytol with other antihistamines?

    Do not combine Nytol with other medicines containing diphenhydramine or other sedating antihistamines unless advised to do so by a healthcare professional.

    Remember that antihistamines can also be present in some cough, cold and allergy medicines.

  • Can I take Nytol with other sleeping medicines?

    Combining Nytol with sleeping medicines, sedatives, tranquillizers or other medicines that cause drowsiness can increase sedation. A pharmacist should check suitability before supply.

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