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- Nytol One-A-Night 50mg – 20 Tablets
Nytol One-A-Night is a sleep aid containing diphenhydramine hydrochloride, a sedating antihistamine used for the temporary relief of sleeplessness in adults and adolescents aged 16 years and over.
Designed for occasional use when you have difficulty falling asleep or staying asleep, Nytol One-A-Night provides a convenient once-nightly dose to help you get a restful night's sleep.
Unlike herbal sleep aids, Nytol One-A-Night contains a conventional medicinal ingredient and is intended for short-term use only.
Active Ingredients
Each tablet contains:
Diphenhydramine Hydrochloride: 50 mg
Dosage and Directions
Adults and adolescents aged 16 years and over:
Take 1 tablet approximately 20 minutes before bedtime.
Swallow with water.
Take only when you have enough time for a full night's sleep.
Do not take more than 1 tablet in 24 hours.
Do not use continuously for longer than 2 weeks without medical advice.
Children under 16 years:
Not recommended.
Warnings and Precautions
- Do not take if you are allergic to diphenhydramine or any other ingredients.
- Do not use during pregnancy or breastfeeding unless advised by a healthcare professional.
- Avoid alcohol while taking this medicine.
- Do not take alongside other medicines containing antihistamines, including certain cough, cold and allergy treatments.
- Do not combine with other sleeping medicines or sedatives unless advised by a healthcare professional.
- May cause drowsiness the following day. Do not drive, cycle or operate machinery if affected.
- Consult your doctor or pharmacist before use if you have glaucoma, difficulty passing urine, prostate problems, breathing difficulties or liver or kidney problems.
- Speak to a healthcare professional if sleep problems persist.
Possible Side Effects
Like all medicines, Nytol One-A-Night can cause side effects, although not everyone experiences them.
Possible side effects include:
- Drowsiness or tiredness the following day
- Dizziness
- Dry mouth
- Difficulty concentrating
- Blurred vision
- Difficulty passing urine
Stop taking the medicine and seek medical advice if you experience severe or unexpected side effects.
Storage Instructions
- Store according to the instructions on the packaging.
- Keep in the original packaging.
- Keep out of the sight and reach of children.
- Do not use after the expiry date printed on the pack.
Always read the label and enclosed Patient Information Leaflet before use. Consult your pharmacist or healthcare professional if you are unsure whether this medicine is suitable for you.


