Priligy 30mg vs 60mg: What’s the Difference?

If you’re looking for treatment for premature ejaculation (PE), you may have seen Priligy available in two strengths: 30mg and 60mg. So, what is the difference between Priligy 30mg and 60mg, and which dose is right for you?

Both contain the same active ingredient, dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for the treatment of premature ejaculation in adult men. The main difference is the amount of dapoxetine in each tablet, and the 60mg dose can provide a greater treatment effect but may also increase the likelihood of side effects.

Priligy 30mg vs 60mg at a glance

Importantly, Priligy should not be taken every day or more than once within 24 hours. The recommended starting dose is 30mg, and the dose may be increased to 60mg when clinically appropriate.

How does Priligy work?

Dapoxetine works by increasing serotonin activity in the nervous system. Serotonin is involved in regulating the ejaculation reflex, and dapoxetine can help increase the time before ejaculation and improve perceived control.

Unlike many traditional SSRIs, dapoxetine is rapidly absorbed and has a relatively short duration of action, making it suitable for on-demand treatment rather than routine daily dosing.

Is Priligy 60mg more effective than 30mg?

Clinical research suggests that both doses can be effective, but studies have generally found a greater increase in intravaginal ejaculatory latency time (IELT) with 60mg compared with 30mg.

An integrated analysis of five Phase III trials involving more than 6,000 men found that average IELT increased from approximately 0.9 minutes at baseline to around 3.1 minutes with 30mg and 3.6 minutes with 60mg at 12 weeks. Both doses performed significantly better than placebo.

A separate analysis of randomised controlled trials similarly found improvements with both doses, with 60mg producing a greater average improvement in IELT.

However, more medication does not necessarily mean the right treatment for every individual. The higher dose has also been associated with a greater frequency of adverse effects.

What are the side effects of Priligy 30mg and 60mg?

As with any medicine, Priligy can cause side effects, although not everyone will experience them.

The most reported side effects include:

Nausea
Dizziness
Headache
Diarrhoea
Stomach discomfort
Fatigue or sleepiness
Difficulty sleeping
Increased sweating
Difficulty concentrating
Erectile difficulties
Nausea, dizziness and headache are classified as very common side effects in the UK patient information leaflet. Other effects, including gastrointestinal symptoms, fatigue, sleep disturbance and erectile difficulties, are classified as common.

How should Priligy be taken?

Priligy should be taken 1 to 3 hours before anticipated sexual activity. The tablet should be swallowed whole with at least one full glass of water.

It should not be taken more than once in 24 hours or used every day.

Priligy is intended for adult men aged 18–64 years with premature ejaculation. It is not suitable for everyone and can interact with certain medicines. Men with particular cardiovascular conditions, a history of fainting or certain other medical conditions may not be suitable for treatment.

Priligy 30mg or 60mg: which one is right for me?

For many men, 30mg is the recommended starting dose. If the response is insufficient and the medicine is well tolerated, a clinician may consider increasing the dose to 60mg.

The British Society for Sexual Medicine's position statement on premature ejaculation supports evidence-based assessment and appropriate use of on-demand dapoxetine as part of PE management.

Get Priligy treatment online with Pharmulous

Premature ejaculation can be difficult to talk about, but getting help doesn't have to involve an uncomfortable face-to-face conversation.

With Pharmulous, you can complete a confidential online assessment from the comfort of your own home. Your information is reviewed by one of our prescribers, who assesses your symptoms, medical history and current medicines to determine whether treatment is suitable.

If Priligy is clinically appropriate for you, your prescription can be dispensed by the Pharmulous pharmacy team and delivered directly to you.

Ready to take the next step? Complete the Pharmulous assessment form today to see how we can help.